Disease as Entropy imbalance

An inherent condition of biological systems is that energy or information flows through their constituents (cells, organelles, molecules). The role of the metabolic work is the reduction of the internal Entropy compared with that of the environment. In open biological systems energy can be replenished allowing the flow of “new” energy to produce more informational or working energy. The system has to stay away from both extremes because if reaches the maximum entropy the system collapses and if the system cannot sustain the tendency towards minimal entropy merge with the rest of the universe, a process known as dissipation. Metasystem transition creates different levels of biological systems according to the degree of complexity. Highest system level is nervous system, the latest evolutionary accompaniment to the lower systems of cellular system and ground system regulation.

An increased of Entropy is undesirable and metabolism has a function to decrease Entropy, since enzymes are efficient to lower Entropy. If a biological system at any instant matches its perfect maximum state it collapses. Atherosclerosis is a maximum entropy status if a biological system reaches a deleterious energy status at the sub-cellular level. The increasing or alternating phases of high and low Entropy disseminates into a cell, then to the whole organ, affecting pertaining system.
Homeostasis is automated by means of continuous information or energy flow. Information are binary bits (0 and 1) maintains feedback loop correction of any given system. The homeostatic controls are energy dependent and as energies diminish, homeostasis as order deteriorates and life is threatened. Either too little or too much energy, as stress, place major burden to homeostatic controls. Accumulation of side metabolites in the matrix or depletion of neurotransmitters and other informational molecules create system void and disease.